{"id":132537,"date":"2022-02-16T08:29:18","date_gmt":"2022-02-16T04:29:18","guid":{"rendered":"https:\/\/split.spnews.io\/?p=132537"},"modified":"2022-02-16T11:39:48","modified_gmt":"2022-02-16T07:39:48","slug":"%e1%83%a5%e1%83%90%e1%83%a0-%e1%83%90%e1%83%9a%e1%83%94%e1%83%a5%e1%83%a1%e1%83%90%e1%83%9c%e1%83%93%e1%83%a0%e1%83%94-%e1%83%97%e1%83%90%e1%83%95%e1%83%90%e1%83%a0%e1%83%97%e1%83%a5%e1%83%98","status":"publish","type":"post","link":"https:\/\/split.spnews.io\/ka\/archives\/132537","title":{"rendered":"\u10d0\u10da\u10d4\u10e5\u10e1\u10d0\u10dc\u10d3\u10e0\u10d4 \u10d7\u10d0\u10d5\u10d0\u10e0\u10d7\u10e5\u10d8\u10da\u10d0\u10eb\u10d4: ,,\u10e0\u10d0\u10e2\u10dd\u10db \u10d0\u10d5\u10d0\u10d3\u10d3\u10d4\u10d1\u10d0 \u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8 COVID-19-\u10d8\u10d7 \u10d3\u10d0 \u10d6\u10dd\u10d2\u10d8 \u10d0\u10e0\u10d0?\u201d \u2013 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd 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\u10db\u10d0\u10db\u10dd\u10eb\u10e0\u10d0\u10d5\u10d4\u10d1\u10d4\u10da\u10d8 \u10d0\u10db \u10d5\u10d8\u10e3\u10e0\u10e3\u10e1\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1 \u10d0\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d7\u10d0\u10d5\u10e3\u10e1\u10d4\u10d1\u10e3\u10e0\u10d4\u10d1\u10d0 (1). \u10de\u10e0\u10dd\u10e4\u10d4\u10e1\u10dd\u10e0\u10d8 \u10d5\u10d8\u10d9\u10d4\u10dc\u10f0\u10d0\u10d2\u10d4\u10dc\u10d8 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d4\u10d1\u10d8 (2) \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10dc, \u10e0\u10dd\u10db \u10db\u10d2\u10e0\u10eb\u10dc\u10dd\u10d1\u10d4\u10da\u10dd\u10d1\u10d0 \u10db\u10eb\u10d8\u10db\u10d4 COVID-19-\u10d7\u10d0\u10dc \u10d0\u10e1\u10dd\u10ea\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10d4\u10e0\u10d7\u10dc\u10e3\u10d9\u10da\u10d4\u10dd\u10e2\u10d8\u10d3\u10e3\u10da\u10d8 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d8\u10d7 (SNP) \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d4\u10dc\u10e8\u10d8 29-59-\u10dd\u10da\u10d8\u10d2\u10dd\u10d0\u10d3\u10d4\u10dc\u10d8\u10da\u10d0\u10e2 \u10e1\u10d8\u10dc\u10d7\u10d4\u10e2\u10d0\u10d6\u10d0-1 (OAS1).<br \/>\n\u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10d3\u10dc\u10d4\u10dc, \u10e0\u10dd\u10db SARS-CoV-2 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e0\u10d3\u10d4\u10e1 \u10d8\u10dc\u10e2\u10d4\u10e0\u10e4\u10d4\u10e0\u10dd\u10dc\u10d8 \u10d2\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 \u10de\u10d0\u10e1\u10e3\u10ee\u10d4\u10d1\u10d8\u10d7, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0 \u10e8\u10dd\u10e0\u10d8\u10e1\u10d0\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 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\u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0\u10d2\u10d0\u10dc \u10d1\u10d4\u10d5\u10e0\u10d8 \u10d9\u10dd\u10d3\u10d8\u10e0\u10d4\u10d1\u10e1 \u10d8\u10e1\u10d4\u10d7\u10d8 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10d0\u10da\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10ea\u10d8\u10da\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0\u10d0, \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10db\u10e8\u10d8\/\u10e3\u10ef\u10e0\u10d4\u10d3\u10e8\u10d8 \u10e8\u10d4\u10db\u10dd\u10ed\u10e0\u10d8\u10da\u10d8 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8\u10e1 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0\u10d8 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d0. \u10d5\u10d8\u10d9\u10d4\u10dc\u10f0\u10d0\u10d2\u10d4\u10dc\u10d8 \u10d3\u10d0 \u10db\u10d8\u10e1\u10d8 \u10ef\u10d2\u10e3\u10e4\u10d8\u10e1 \u10e8\u10e0\u10dd\u10db\u10d4\u10d1\u10d8 \u10d3\u10d4\u10e2\u10d0\u10da\u10e3\u10e0\u10d0\u10d3 \u10e8\u10d4\u10d8\u10e1\u10ec\u10d0\u10d5\u10da\u10d4\u10e1, \u10e0\u10dd\u10db \u10d4\u10de\u10dd\u10d5\u10d0\u10d7 \u10db\u10e0\u10d0\u10d5\u10d0\u10da\u10d8 \u10d0\u10e1\u10d4\u10e3\u10da\u10d8 \u10d0\u10e1\u10d4\u10e3\u10da\u10d8 \u10ea\u10d8\u10da\u10d8\u10d3\u10d0\u10dc \u10d8\u10e1 \u10ef\u10d2\u10e3\u10e4\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10e4\u10da\u10dd\u10d1\u10d4\u10dc SARS-CoV-2-\u10d8\u10e1 \u10e1\u10e3\u10de\u10e0\u10d4\u10e1\u10d8\u10d8\u10e1 \u10e3\u10dc\u10d0\u10e0\u10e1 \u10d3\u10d0 \u10d3\u10d0\u10d0\u10d3\u10d2\u10d8\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 OAS1 \u10ea\u10d8\u10da\u10d0 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10eb\u10da\u10d8\u10d4\u10e0 \u10d3\u10d0\u10db\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d4\u10da \u10d7\u10d5\u10d8\u10e1\u10d4\u10d1\u10d4\u10d1\u10e1 \u10e4\u10da\u10dd\u10d1\u10d3\u10d0 SARS-CoV-2-\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2. \u10d4\u10e0\u10d7\u10d8\u10e1 \u10db\u10ee\u10e0\u10d8\u10d5 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8 OAS1 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d8\u10d7 \u10d0\u10e0\u10d8\u10d0\u10dc \u10db\u10d8\u10d3\u10e0\u10d4\u10d9\u10d8\u10da\u10d8 \u10db\u10eb\u10d8\u10db\u10d4 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7, \u10db\u10d4\u10dd\u10e0\u10d4\u10e1 \u10db\u10ee\u10e0\u10d8\u10d5 OAS1 \u10ea\u10d8\u10da\u10d0 \u10ee\u10d0\u10e1\u10d8\u10d0\u10d7\u10d3\u10d4\u10d1\u10d0 \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 SARS-CoV-2-\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10d7.<br \/>\nOAS1 \u10ea\u10d8\u10da\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10e4\u10d4\u10e0\u10db\u10d4\u10dc\u10e2\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10e5\u10e2\u10d8\u10d5\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10dd\u10e0\u10ef\u10d0\u10ed\u10d5\u10d8\u10d0\u10dc\u10d8 \u10e0\u10dc\u10db-\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1, \u10d4\u10e1 \u10e3\u10d9\u10d0\u10dc\u10d0\u10e1\u10d9\u10dc\u10d4\u10da\u10d8 \u10db\u10d8\u10db\u10dd\u10e4\u10d0\u10dc\u10e2\u10e3\u10da\u10d8\u10d0 \u10d4\u10e0\u10d7\u10ef\u10ed\u10d5\u10d8\u10d0\u10dc\u10d8 SARS-CoV-2 \u10d2\u10d4\u10dc\u10dd\u10db\u10d8\u10e1 \u10d2\u10d0\u10e1\u10ec\u10d5\u10e0\u10d8\u10d5. \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 OAS1 \u10ea\u10d8\u10da\u10d0 \u10d0\u10d9\u10d0\u10e2\u10d0\u10da\u10d8\u10d6\u10d4\u10d1\u10e1 \u10d0\u10d3\u10d4\u10dc\u10dd\u10d6\u10d8\u10dc\u10e2\u10e0\u10d8\u10e4\u10dd\u10e1\u10e4\u10d0\u10e2\u10d8\u10e1 (ATP) \u10de\u10dd\u10da\u10d8\u10db\u10d4\u10e0\u10d8\u10d6\u10d0\u10ea\u10d8\u10d0\u10e1 \u10db\u10d4\u10dd\u10e0\u10d0\u10d3 \u10db\u10d4\u10e1\u10d4\u10dc\u10ef\u10d4\u10e0\u10e8\u10d8 \u2013 29-59-\u10dd\u10da\u10d8\u10d2\u10dd\u10d0\u10d3\u10d4\u10dc\u10d8\u10da\u10d0\u10e2\u10d8.<br \/>\nOAS1 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d0\u10d3 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10dd\u10e0\u10d8 \u10d8\u10d6\u10dd\u10e4\u10dd\u10e0\u10db\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d8\u10d7 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u2013 \u10e3\u10e4\u10e0\u10dd \u10d2\u10e0\u10eb\u10d4\u10da\u10d8 \u10d8\u10d6\u10dd\u10e4\u10dd\u10e0\u10db\u10d0 (p46) \u10d3\u10d0 \u10db\u10dd\u10d9\u10da\u10d4 \u10d5\u10d4\u10e0\u10e1\u10d8\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d1\u10d8\u10dd\u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d4\u10d1\u10e8\u10d8 (p42). \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10ea\u10d5\u10d0\u10da\u10d4\u10d1\u10d0\u10d3\u10dd\u10d1\u10d0 \u10d2\u10d0\u10dc\u10d0\u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e1 \u10d7\u10e3 \u10e0\u10dd\u10db\u10d4\u10da\u10d8 \u10d8\u10d6\u10dd\u10e4\u10dd\u10e0\u10db\u10d0 \u10d8\u10e5\u10dc\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10ee\u10d0\u10e2\u10e3\u10da\u10d8. \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8, p46 \u10d4\u10e5\u10e1\u10de\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d8\u10db \u10ee\u10d0\u10da\u10ee\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d0\u10e5\u10d5\u10d7 SNP, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10e0\u10d8\u10e1 \u10db\u10d8\u10d6\u10d4\u10d6\u10d8OAS1 \u10db\u10d4\u10e1\u10d8\u10dc\u10ef\u10d4\u10e0\u10d8 \u10e0\u10dc\u10db-\u10d8\u10e1 (mRNA) \u10d0\u10da\u10e2\u10d4\u10e0\u10dc\u10d0\u10e2\u10d8\u10e3\u10da \u10d2\u10d0\u10d3\u10d0\u10d1\u10db\u10d8\u10e1 (\u10e1\u10de\u10da\u10d0\u10d8\u10e1\u10d8\u10dc\u10d2\u10d8). \u10d4\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e0\u10d8\u10e1 \u10e2\u10d4\u10e0\u10db\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10d4\u10d2\u10d6\u10dd\u10dc\u10d8\u10e1 \u10e4\u10dd\u10e0\u10db\u10d8\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8 \u10e9\u10d0\u10e0\u10d7\u10e3\u10da\u10d8, \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 p42-\u10d8\u10e1 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1. \u10d0\u10db\u10e0\u10d8\u10d2\u10d0\u10d3, p46 OAS1 \u10e0\u10dc\u10db-\u10d8\u10e1 \u10d9\u10d0\u10e0\u10d1\u10dd\u10e5\u10e1\u10d8\u10da\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d1\u10dd\u10da\u10dd\u10d4\u10d1\u10d0 \u10d4.\u10ec. \u10e2\u10d4\u10e0\u10db\u10d8\u10dc\u10d0\u10da\u10d8 \u10e8\u10d4\u10d8\u10ea\u10d0\u10d5\u10e1 \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10e3\u10da\u10d8 \u10dd\u10d7\u10ee\u10d8 \u10d0\u10db\u10d8\u10dc\u10dd\u10db\u10df\u10d0\u10d5\u10d8\u10e1 \u10e2\u10e0\u10d8\u10de\u10da\u10d4\u10e2\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e5\u10db\u10dc\u10d8\u10e1 \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d0\u10d3\u10d2\u10d8\u10da\u10e1. \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d0\u10ea\u10d8\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10de\u10dd\u10e1\u10e2\u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10db\u10dd\u10d3\u10d8\u10e4\u10d8\u10d9\u10d0\u10ea\u10d8\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d6\u10dc\u10dd\u10d1\u10e0\u10d8\u10d5 \u10d2\u10d0\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10d1\u10d0\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d0\u10e8\u10d8.<br \/>\n\u10e0\u10d0\u10e2\u10dd\u10db \u10d0\u10e0\u10d8\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8? SARSCoV-2, \u10d8\u10e1\u10d4\u10d5\u10d4 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e7\u10d5\u10d4\u10da\u10d0 \u10d9\u10dd\u10e0\u10dd\u10dc\u10d0\u10d5\u10d8\u10e0\u10e3\u10e1\u10d8, \u10d8\u10e0\u10e9\u10d4\u10d5\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d4\u10dc\u10d3\u10dd\u10de\u10da\u10d0\u10d6\u10db\u10e3\u10e0\u10d8 \u10d1\u10d0\u10d3\u10d8\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db \u10e8\u10d4\u10eb\u10da\u10dd\u10dc \u10e6\u10e0\u10e3\u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d8\u10d0\u10dc\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10d0\u10d9\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0, \u10e1\u10d0\u10d3\u10d0\u10ea \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10db\u10d8\u10e1\u10d8 \u10d2\u10d4\u10dc\u10dd\u10db\u10d8\u10e1 \u10d2\u10d0\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10d1\u10d0\u10e1. \u10d0\u10db\u10e0\u10d8\u10d2\u10d0\u10d3, \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10e3\u10da\u10d8 OAS1 p46 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da\u10d0\u10d3 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10dc\u10db \u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8\u10d7, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10ec\u10d0\u10e0\u10db\u10dd\u10d8\u10e5\u10db\u10dc\u10d4\u10d1\u10d0 \u10d4.\u10ec. \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 \u10d5\u10d4\u10d6\u10d8\u10d9\u10e3\u10da\u10d4\u10d1\u10d8 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10db\u10dd\u10db\u10d0\u10d5\u10d0\u10da\u10d8 \u10e0\u10d4\u10de\u10da\u10d8\u10d9\u10d0\u10ea\u10d8\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1\/\u10d2\u10d0\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10d1\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1. \u10db\u10d0\u10e0\u10d7\u10da\u10d0\u10ea, \u10d3\u10d0\u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d8\u10e0\u10e3\u10e1\u10d8 A, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e5\u10db\u10dc\u10d8\u10e1 \u10d5\u10d4\u10d6\u10d8\u10d9\u10e3\u10da\u10e3\u10e0 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10e3\u10da \u10e1\u10e2\u10e0\u10e3\u10e5\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1, \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd OAS1-\u10d8\u10d7. \u10de\u10d8\u10e0\u10d8\u10e5\u10d8\u10d7, \u10e1\u10ee\u10d5\u10d0 \u10e0\u10d4\u10e1\u10de\u10d8\u10e0\u10d0\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10e0\u10dc\u10db \u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10de\u10d0\u10e0\u10d0\u10d2\u10e0\u10d8\u10de\u10d8\u10e1 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8\u10e1 \u10e2\u10d8\u10de\u10d8 3 \u10d3\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10e0\u10d4\u10e1\u10de\u10d8\u10e0\u10d0\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10e1\u10d8\u10dc\u10ea\u10d8\u10e2\u10d8\u10e3\u10e0\u10d8 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10e3\u10da\u10d8 \u10d5\u10d4\u10d6\u10d8\u10d9\u10e3\u10da\u10d4\u10d1\u10d8 \u10e0\u10d4\u10de\u10da\u10d8\u10d9\u10d0\u10ea\u10d8\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10d0\u10e0 \u10d8\u10e7\u10dd \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10e3\u10da\u10d8 p46-\u10d8\u10d7.<br \/>\n\u10d5\u10d8\u10d9\u10d4\u10dc\u10f0\u10d0\u10d2\u10d4\u10dc\u10db\u10d0 \u10d3\u10d0 \u10db\u10d8\u10e1\u10db\u10d0 \u10ef\u10d2\u10e3\u10e4\u10db\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10d9\u10d5\u10da\u10d8\u10d0 \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8\u10d6\u10d4\u10d1\u10e3\u10da\u10d8 499 COVID-19 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d9\u10dd\u10f0\u10dd\u10e0\u10e2\u10d0 \u10d3\u10d8\u10d3 \u10d1\u10e0\u10d8\u10e2\u10d0\u10dc\u10d4\u10d7\u10e8\u10d8. \u10d5\u10d8\u10dc\u10d0\u10d8\u10d3\u10d0\u10dc \u10e7\u10d5\u10d4\u10da\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10e1 \u10d0\u10e6\u10d4\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10dd\u10d3\u10d0 OAS1-\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10e0\u10d4\u10e1\u10d8\u10d0, \u10db\u10d0\u10d7\u10d2\u10d0\u10dc 42,5%-\u10db\u10d0 \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10ee\u10d0\u10e2\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 p46 \u10d8\u10d6\u10dd\u10e4\u10dd\u10e0\u10db\u10d0. \u10d4\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 \u10e1\u10e2\u10d0\u10e2\u10d8\u10e1\u10e2\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10d8\u10e7\u10d5\u10dc\u10d4\u10dc \u10e3\u10e4\u10e0\u10dd \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd, \u10e0\u10dd\u10db \u10f0\u10e5\u10dd\u10dc\u10dd\u10d3\u10d0\u10d7 \u10db\u10eb\u10d8\u10db\u10d4 COVID-19 (\u10e8\u10d4\u10d8\u10e7\u10d5\u10d0\u10dc\u10d4\u10e1 \u10d8\u10dc\u10e2\u10d4\u10dc\u10e1\u10d8\u10e3\u10e0\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0\u10e8\u10d8). \u10d4\u10e1 \u10e4\u10d0\u10e5\u10e2\u10d8 \u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db OAS1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea SARS-CoV-2 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e1 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8 \u10d3\u10d0 \u10e0\u10dd\u10db \u10db\u10d8\u10e1\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10dd\u10d1\u10e0\u10d8\u10d5\u10d8 \u10e3\u10e3\u10dc\u10d0\u10e0\u10dd\u10d1\u10d0 \u10d2\u10d0\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10dd\u10e1 RnaseL (L-\u10e0\u10d8\u10d1\u10dd\u10dc\u10e3\u10d9\u10da\u10d4\u10d0\u10d6\u10d4\u10d1\u10d8), \u10e0\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d0\u10d3\u10d0\u10ea \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4\u10dd\u10d1\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0 \u10db\u10eb\u10d8\u10db\u10d4 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d8\u10d7, \u10d7\u10e3\u10db\u10ea\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd\u10d3, \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1.<br \/>\n\u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10db\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d2\u10d0\u10db\u10dd\u10d8\u10d9\u10d5\u10da\u10d8\u10d4\u10e1 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10d4\u10d1\u10d8 \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0\u10ea \u10d2\u10d0\u10d3\u10d0\u10d0\u10e5\u10d5\u10d7 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10d9\u10dd\u10e0\u10dd\u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8. \u1c9b\u10d0\u10d7 \u10d8\u10de\u10dd\u10d5\u10d4\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0 \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 OAS1 \u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8, \u10eb\u10e0\u10dd\u10ee\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0 \u10d0\u10e5\u10da\u10d4\u10db\u10d4\u10d1\u10e8\u10d8. \u10d0\u10e6\u10e1\u10d0\u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10d8\u10d0, \u10ea\u10ee\u10d4\u10dc\u10dd\u10e1\u10d0\u10dc\u10d8 \u10e6\u10d0\u10db\u10e3\u10e0\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10d7\u10d5\u10da\u10d4\u10d1\u10d8\u10d0\u10dc \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10e0\u10d4\u10d6\u10d4\u10e0\u10d5\u10e3\u10d0\u10e0\u10d4\u10d1\u10d0\u10d3 SARS-\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d9\u10dd\u10e0\u10dd\u10dc\u10d0\u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 (4), \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10e3\u10da\u10d8 \u10d0\u10e5\u10d5\u10d7 \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d0\u10d3\u10d2\u10d8\u10da\u10d8 \u10db\u10d0\u10d7 OAS1-\u10e8\u10d8, \u10d4\u10e1 \u10d0\u10e0\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10d2\u10d4\u10dc\u10dd\u10db\u10e3\u10e0\u10d8 \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 (\u10d0\u10dc\u10e3 \u10d2\u10d4\u10dc\u10dd\u10db\u10e3\u10e0\u10d8 \u10db\u10e3\u10e2\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1), \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10db\u10d0\u10ea OAS1 \u10e0\u10dc\u10db-\u10e8\u10d8 \u10d0\u10e6\u10db\u10dd\u10e4\u10ee\u10d5\u10e0\u10d0 \u10d9\u10e0\u10d8\u10e2\u10d8\u10d9\u10e3\u10da\u10d8 \u10dd\u10d7\u10ee\u10d8 \u10d0\u10db\u10d8\u10dc\u10dd\u10db\u10df\u10d0\u10d5\u10d8\u10e1 \u10e2\u10e0\u10d8\u10de\u10da\u10d4\u10e2\u10d8, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3 \u10d0\u10db \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10d7\u10d0\u10e0\u10d2\u10d4\u10d7\u10e3\u10da\u10d8 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10e3\u10da\u10d8 \u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10e3\u10e5\u10dd\u10dc\u10da\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd \u10d2\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d5\u10d8\u10d7\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0. \u10ea\u10ee\u10d4\u10dc\u10d8\u10e1 \u10e6\u10d0\u10db\u10e3\u10e0\u10d0 (Rhinolophus ferrumequinum) OAS1 \u10d8\u10e7\u10dd \u10d0\u10e0 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 SARS-CoV-2 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10d9\u10e3\u10da\u10e2\u10e3\u10e0\u10d0\u10e8\u10d8. \u10de\u10d8\u10e0\u10d8\u10e5\u10d8\u10d7, \u10e8\u10d0\u10d5\u10d8 \u10db\u10e4\u10e0\u10d8\u10dc\u10d0\u10d5\u10d8 \u10db\u10d4\u10da\u10d0 (Pteropus alecto) \u2013 \u10e6\u10d0\u10db\u10e3\u10e0\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d6\u10d4\u10e0\u10d5\u10e3\u10d0\u10e0\u10d8 \u10dc\u10d8\u10e4\u10d0 \u10d3\u10d0 \u10f0\u10d4\u10dc\u10d3\u10e0\u10d0 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10e0\u10dd\u10db\u10d4\u10da\u10e1\u10d0\u10ea \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d7\u10d0 \u10d3\u10d0\u10d8\u10dc\u10e4\u10d8\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10ea \u2013 \u10e4\u10da\u10dd\u10d1\u10e1 \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d8\u10e0\u10d4\u10d1\u10e3\u10da OAS1-\u10e1, \u10e0\u10dd\u10db\u10d4\u10da\u10e1\u10d0\u10ea \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10dd\u10e1 SARSCoV-2. \u10d4\u10e1 \u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d4\u10d1\u10d8 \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db \u10ea\u10ee\u10d4\u10dc\u10dd\u10e1\u10d0\u10dc\u10d8 \u10e6\u10d0\u10db\u10e3\u10e0\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10d3\u10d0 \u10d4\u10d5\u10dd\u10da\u10e3\u10ea\u10d8\u10e3\u10e0\u10d0\u10d3 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d0\u10d3\u10d8 \u10e0\u10d4\u10d6\u10d4\u10e0\u10d5\u10e3\u10d0\u10e0\u10d8 \u10d3\u10d0 \u10dd\u10de\u10e2\u10d8\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u10db\u10d0\u10e1\u10de\u10d8\u10dc\u10eb\u10da\u10d4\u10d1\u10d8 \u10d9\u10dd\u10e0\u10dd\u10dc\u10d0\u10d5\u10d8\u10e0\u10e3\u10e1\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 SARS-CoV-2.<br \/>\n\u10d0\u10dc\u10d7\u10e0\u10dd\u10de\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10db\u10d0 \u10d3\u10d0 \u10ea\u10d8\u10e2\u10dd\u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10db\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10db\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db p46 OAS1 \u10d5\u10d0\u10e0\u10d8\u10d0\u10dc\u10e2\u10d8, \u10ec\u10d0\u10e0\u10db\u10dd\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d4\u10dc\u10dd\u10db\u10e8\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10dc\u10d4\u10d0\u10dc\u10d3\u10d4\u10e0\u10e2\u10d0\u10da\u10d4\u10da\u10d4\u10d1\u10d8\u10e1\u10d2\u10d0\u10dc \u10db\u10d4\u10db\u10d9\u10d5\u10d8\u10d3\u10e0\u10d4\u10dd\u10d1\u10d8\u10d7 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8 \u10da\u10dd\u10d9\u10e3\u10e1\u10e1 (5\u20137), \u10e0\u10d0\u10ea \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 COVID-19-\u10d8\u10e1 \u10db\u10eb\u10d8\u10db\u10d4 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1\u10d0\u10d2\u10d0\u10dc \u10d3\u10d0\u10ea\u10d5\u10d0\u10e1 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d0\u10e8\u10d8 (8, 9). \u10d4\u10e1 \u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d4\u10d1\u10d8 \u10d0\u10e1\u10d0\u10ee\u10d0\u10d5\u10e1 \u10ec\u10d8\u10dc\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e1\u10d0\u10ea, \u10e0\u10d0\u10ea \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1 \u10e0\u10dd\u10db \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d3\u10d0\u10e1\u10d0\u10d5\u10da\u10d4\u10d7 \u10dc\u10d8\u10da\u10dd\u10e1\u10d8\u10e1 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8\u10d7 (10) \u10d3\u10d0 C \u10f0\u10d4\u10de\u10d0\u10e2\u10d8\u10e2\u10d8\u10e1 \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8\u10e1 (11) \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d0, \u10dd\u10e0\u10d8\u10d5\u10d4 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10e3\u10da \u10d5\u10d4\u10d6\u10d8\u10d9\u10e3\u10da\u10d4\u10d1\u10e1 \u10e0\u10d4\u10de\u10da\u10d8\u10d9\u10d0\u10ea\u10d8\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0 \u10ea\u10d5\u10d0\u10da\u10d4\u10d1\u10d0\u10d3\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 OAS1 \u10da\u10dd\u10d9\u10e3\u10e1\u10e8\u10d8. \u10d9\u10d8\u10d3\u10d4\u10d5 \u10d4\u10e0\u10d7\u10d8 \u10d4\u10da\u10d4\u10d2\u10d0\u10dc\u10e2\u10e3\u10e0\u10d8 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10d0\u10d5\u10e1\u10d4\u10d1\u10e1 \u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d4\u10d1\u10e1 \u10d5\u10d8\u10d9\u10d4\u10dc\u10f0\u10d0\u10d2\u10d4\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d8\u10e1\u10d8 \u10ef\u10d2\u10e3\u10e4\u10d8\u10e1, \u10d8\u10db\u10d8\u10e1 \u10d3\u10d4\u10db\u10dd\u10dc\u10e1\u10e2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d8\u10d7 \u10e0\u10dd\u10db \u10de\u10e0\u10d4\u10dc\u10d8\u10da\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 OAS1 \u10d0\u10e4\u10d4\u10e0\u10ee\u10d4\u10d1\u10e1 \u10db\u10e0\u10d0\u10d5\u10d0\u10da \u10d5\u10d8\u10e0\u10e3\u10e1\u10e1, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 SARS-CoV-2 \u10d3\u10d0 \u10d0\u10e1\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10db\u10eb\u10d8\u10db\u10d4 COVID-19-\u10d8\u10e1\u10d2\u10d0\u10dc \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0\u10ea\u10d5\u10d8\u10d7 (12).<br \/>\n\u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10db\u10d6\u10d0\u10e0\u10d3\u10d8 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e3\u10d6\u10e0\u10e3\u10dc\u10d5\u10d4\u10da\u10e7\u10dd\u10e4\u10e1 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10d9\u10e0\u10d8\u10e2\u10d8\u10d9\u10e3\u10da \u10d2\u10d0\u10d2\u10d4\u10d1\u10d0\u10e1, \u10e0\u10dd\u10db \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10ea\u10d5\u10d0\u10da\u10d4\u10d1\u10d0\u10d3\u10dd\u10d1\u10d0 \u10d0\u10e7\u10d0\u10da\u10d8\u10d1\u10d4\u10d1\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10e1 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 COVID-19. OAS1-\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d3\u10d0, \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10ea\u10d5\u10d0\u10da\u10d4\u10d1\u10d0\u10d3\u10dd\u10d1\u10d0 \u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 \u10e0\u10dc\u10db-\u10d8\u10e1 \u10e1\u10ee\u10d0 \u10e1\u10d4\u10dc\u10e1\u10dd\u10e0\u10e3\u10da \u10e3\u10d1\u10dc\u10d4\u10d1\u10e8\u10d8, \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3 Toll-\u10d8\u10e1 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8-7 (TLR7), \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10db\u10eb\u10d8\u10db\u10d4 COVID-19-\u10d7\u10d0\u10dc (13\u201315). \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e9\u10d0\u10dc\u10e1, \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8 \u10d4\u10e5\u10e1\u10d9\u10da\u10e3\u10d6\u10d8\u10e3\u10e0\u10d8\u10d0 \u10db\u10d0\u10db\u10d0\u10d9\u10d0\u10ea\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc TLR7 \u10d0\u10e0\u10d8\u10e1 X \u10e5\u10e0\u10dd\u10db\u10dd\u10e1\u10dd\u10db\u10d0\u10d6\u10d4, \u10d0\u10e1\u10d4 \u10db\u10d4\u10db\u10d9\u10d5\u10d8\u10d3\u10e0\u10d4\u10dd\u10d1\u10d8\u10d7 \u10db\u10d0\u10d5\u10dc\u10d4 \u10db\u10e3\u10e2\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8 TLR7-\u10e8\u10d8, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d1\u10d0\u10da \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d0\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d5\u10d4\u10e0 \u10d0\u10ec\u10d0\u10e0\u10db\u10dd\u10d4\u10d1\u10d4\u10dc \u10d8\u10dc\u10e2\u10d4\u10e0\u10e4\u10d4\u10e0\u10dd\u10dc\u10d8\u10e1 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10d0\u10e1, \u10e0\u10d0\u10ea \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 COVID-19-\u10d8\u10e1 \u10e3\u10e4\u10e0\u10dd \u10db\u10eb\u10d8\u10db\u10d4 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc. \u10e9\u10d5\u10d4\u10dc\u10d8 \u10ea\u10dd\u10d3\u10dc\u10d0 \u10db\u10d0\u10e1\u10de\u10d8\u10dc\u10eb\u10da\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10e1\u10ec\u10e0\u10d0\u10e4\u10d0\u10d3 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0. \u10d1\u10d4\u10d5\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10ee\u10d3\u10d4\u10d1\u10d0 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8 \u10d8\u10db\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d4\u10d1\u10d4\u10dc SARS-CoV-2-\u10e1. \u10d4\u10e1 \u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d4\u10d1\u10d8 \u10e3\u10d3\u10d0\u10d5\u10dd\u10d3 \u10d8\u10e5\u10dc\u10d4\u10d1\u10d0 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d2\u10d6\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10ee\u10e1\u10dc\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10ec\u10e7\u10d8\u10e1\u10d8 SARSCoV-2-\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d8\u10d5\u10d8\u10e0\u10e3\u10e1\u10e3\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10d8\u10e2\u10d4\u10e2\u10d8 \u10e3\u10ef\u10d4\u10d7 \u10d2\u10d0\u10d2\u10d4\u10d1\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1 \u10d3\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10e1\u10d0\u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10da\u10dd \u10d0\u10e6\u10db\u10dd\u10e9\u10dc\u10d3\u10d4\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10e2\u10e0\u10d0\u10e2\u10d4\u10d2\u10d8\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10e3\u10e8\u10d0\u10d5\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10eb\u10d8\u10db\u10d4 COVID-19-\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d0\u10dc \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1.<br \/>\n\u10e7\u10dd\u10d5\u10d4\u10da\u10d8\u10d5\u10d4 \u10d6\u10dd\u10db\u10dd\u10d7\u10e5\u10db\u10e3\u10da\u10d8\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4 \u10e8\u10d4\u10d2\u10d5\u10d8\u10eb\u10da\u10d8\u10d0 \u10d3\u10d0\u10d5\u10d0\u10e1\u10d9\u10d5\u10dc\u10d0\u10d7, \u10e0\u10dd\u10db SARS-CoV-2 \u10d2\u10d4\u10dc\u10dd\u10db\u10d8 \u10e3\u10db\u10d8\u10d9\u10d0\u10da\u10e3\u10e0\u10d8\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1\u10d8 \u10e1\u10e2\u10e0\u10e3\u10e5\u10e2\u10e3\u10e0\u10e3\u10da\u10d8 \u10d7\u10d5\u10d8\u10e1\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7 \u10d3\u10d0 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d7\u10d0\u10d5\u10d8\u10e1\u10d4\u10d1\u10e3\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7. \u10dd\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 \u10d8\u10e1, \u10e0\u10dd\u10db \u10ef\u10d4\u10e0 \u10d0\u10e0\u10ea \u10d4\u10e0\u10d7 \u10e0\u10dc\u10db \u10d5\u10d8\u10e0\u10e3\u10e1\u10e8\u10d8 \u10d0\u10e0\u10d0\u10e0\u10d8\u10e1 \u10d0\u10db\u10d3\u10d4\u10dc\u10d8 \u10dc\u10e3\u10d9\u10da\u10d4\u10dd\u10e2\u10d8\u10d3\u10d8 \u10e3\u10e0\u10d0\u10ea\u10d8\u10da\u10d8\u10e1 \u10dc\u10d0\u10e8\u10d7\u10d8 (\u10e0\u10d0\u10ea \u10db\u10d8\u10e1 \u10ee\u10d4\u10da\u10dd\u10d8\u10d5\u10dc\u10e3\u10e0 \u10e8\u10d4\u10e5\u10db\u10dc\u10d0\u10e1 \u10d1\u10d4\u10d5\u10e0\u10d0\u10d3 \u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1 \u10d5\u10d8\u10d3\u10e0\u10d4 \u10d4\u10d5\u10dd\u10da\u10e3\u10ea\u10d8\u10d8\u10e1 \u10d9\u10d8\u10d1\u10d4\u10d6\u10d4 \u10d0\u10e6\u10db\u10dd\u10ea\u10d4\u10dc\u10d4\u10d1\u10d0\u10e1), \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e9\u10d5\u10d4\u10dc\u10e1 \u10ec\u10d8\u10dc\u10d0\u10de\u10e0\u10d4\u10d1\u10e8\u10d8 \u2013 \u10dc\u10d4\u10d0\u10dc\u10d3\u10d4\u10e0\u10e2\u10d0\u10da\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10d7\u10d8\u10d7\u10e5\u10dd\u10e1\u10d3\u10d0 \u10db\u10d8\u10e1\u10e2\u10d8\u10e3\u10e0\u10d0\u10d3 \u10e9\u10d0\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 COVID-19-\u10d8\u10e1 \u10db\u10eb\u10d8\u10db\u10d4 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1\u10d0\u10d2\u10d0\u10dc \u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10d8 \u10e3\u10e4\u10e0\u10dd \u10d8\u10d3\u10e3\u10db\u10d0\u10da\u10e1 \u10ee\u10d3\u10d8\u10e1 \u10d0\u10db \u10d5\u10d8\u10e0\u10e3\u10e1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10ea\u10d4\u10dc\u10d4\u10d1\u10d0\u10e1, \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d3\u10d0 \u10d5\u10d8\u10e0\u10e3\u10e1\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d9\u10e3\u10d7\u10ee\u10d8\u10d7 \u10d9\u10d8 2 \u10ec\u10da\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10d0\u10db\u10d3\u10d4\u10dc\u10d8 \u10db\u10e3\u10e2\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d0, \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1\u10d0\u10d2\u10d0\u10dc \u10d2\u10d0\u10e1\u10ee\u10da\u10e2\u10dd\u10db\u10d0 \u10d3\u10d0 \u10de\u10dd\u10e1\u10e2\u10d9\u10dd\u10d5\u10d8\u10d3\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10ea\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10ea\u10d4\u10dc\u10d4\u10d1\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10d3\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d8\u10d0 \u10d4\u10e0\u10d7\u10d8 \u10e1\u10d0\u10d9\u10d8\u10d7\u10ee\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7: \u10d0\u10db 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